148P: Concordance between detection of EGFR mutations on tissue and in circulating free tumor DNA (cftDNA) in newly diagnosed metastatic lung adenocarcinoma (mLA)

The detection of EGFR mutations may predict sensitivity to EGFR-TKIs (Tyrosine Kinases Inhibitors) in mLA. However, small biopsies or cytological samples often provide limited or insufficient tumor tissue for molecular analysis. Moreover, a re-biopsy is not always technically feasible to identify emerging mechanisms of resistance at disease progression. Therefore, cftDNA represents an alternative source of DNA for genotyping the tumor. Patients...