Malondialdehyde

Streptozotocin

Cholesterol

Endocrinology

Hemoglobin

Biochemistry

Peganum harmala

Oxidative stress

Antioxidant

Internal medicine

Pharmacology

Medicine

Chemistry

Saline

Traditional medicine

Bilirubin

Diabetes mellitus

The present study was carried out to investigate the antidiabetic and antihyperlipidemic properties of hydroalcoholic extract of Peganum harmala in streptozotocin-induced diabetic male rats. In an experimental study, 64 normal Wistar albino male rats (200–230 g) were randomly divided into 8 groups. Control and diabetic rats were treated with normal saline and three different doses (30, 60, and 120 mg/kg) of hydroalcoholic extract of Peganum harmala seeds for 4 weeks orally. At the end of treatment, blood samples were taken and glucose, triglycerides, total cholesterol, LDL-c, HDL-c, malondialdehyde (MDA), total antioxidant capacity (TCA), ALT, AST, GGT, bilirubin, and glycosylated hemoglobin (<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="M1"><mml:mrow><mml:msub><mml:mrow><mml:mi mathvariant="normal">H</mml:mi><mml:mi mathvariant="normal">b</mml:mi><mml:mi mathvariant="normal">A</mml:mi></mml:mrow><mml:mrow><mml:mn mathvariant="normal">1</mml:mn><mml:mi mathvariant="normal">C</mml:mi></mml:mrow></mml:msub></mml:mrow></mml:math>) were determined. STZ-induced diabetic rats showed significant changes in the values of glucose, triglycerides, total cholesterol, LDL-c, MDA, TAC, ALT, AST, GGT, bilirubin, and <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="M2"><mml:mrow><mml:msub><mml:mrow><mml:mi mathvariant="normal">H</mml:mi><mml:mi mathvariant="normal">b</mml:mi><mml:mi mathvariant="normal">A</mml:mi></mml:mrow><mml:mrow><mml:mn mathvariant="normal">1</mml:mn><mml:mi mathvariant="normal">C</mml:mi></mml:mrow></mml:msub></mml:mrow></mml:math> in comparison with normal rats. Administration of the extract to diabetic rats resulted in a remarkable decrease in glucose, lipid profiles, MDA, ALT, AST, GGT, bilirubin, and <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="M3"><mml:mrow><mml:msub><mml:mrow><mml:mi mathvariant="normal">H</mml:mi><mml:mi mathvariant="normal">b</mml:mi><mml:mi mathvariant="normal">A</mml:mi></mml:mrow><mml:mrow><mml:mn mathvariant="normal">1</mml:mn><mml:mi mathvariant="normal">C</mml:mi></mml:mrow></mml:msub></mml:mrow></mml:math> levels and increase in TAC relative to diabetic group. The results of this study indicated that hydroalcoholic extract of Peganum harmala seeds possesses antidiabetic and hypolipidemic activities and could be useful in treatment of diabetes.

Evaluation of Antidiabetic and Antihyperlipidemic Effects of <i>Peganum harmala</i> Seeds in Diabetic Rats

Evaluation of Antidiabetic and Antihyperlipidemic Effects of Peganum harmala Seeds in Diabetic Rats