Abstract B36: Human serum albumin and affibody fusion proteins for targeted drug delivery to HER2 positive cells

Human Epidermal growth factor Receptor 2 (HER2) has been reported to be over-expressed in 20-30% of the breast cancer patients and related to poor prognosis. Affibody ZHER2 is a small protein which has high affinity to HER2 screened by phage display. Human Serum Albumin (HSA), as the main protein in plasma, has been commonly used to extend the small peptides serum half-life. Its high solubility, stability and excellent ability to carry multiple...