Dynamin II is required for 17β-estradiol signaling and autophagy-based ERα degradation
Abstract
17β-estradiol (E2) regulates diverse physiological effects, including cell proliferation, by binding to estrogen receptor α (ERα). ERα is both a transcription factor that drives E2-sensitive gene expression and an extra-nuclear localized receptor that triggers the activation of diverse kinase cascades. While E2 triggers cell proliferation, it also induces ERα degradation in a typical hormone-dependent feedback loop. Although ERα breakdown...
Paper Details
Title
Dynamin II is required for 17β-estradiol signaling and autophagy-based ERα degradation
Published Date
Mar 24, 2016
Journal
Volume
6
Issue
1
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