<p>The objective of this research was to determine the effects of Protexin®, Fermacto® and its compounded effects on growth performance, visceral organs weight, insulin, thyroxin and growth hormone of Japanese quails. Growth performance with respect to body weight gain and visceral organs weight were recorded and then blood sampling were taken for analysis of serum hormones using ELISA technique. The analyzing of data in completely randomized design showed that consumption of each Fermacto® and Protexin®+Fermacto® caused elevation in feed intake and body weight (p<0.05). The gizzard weight in males fed Fermacto® was decreased and in females fed all additives, especially protexin® was elevated (p<0.05). Males and Females fed Fermacto® have lighter intestines weight than other additive groups (p<0.05). The heart weight in males fed additives were reduced and in females fed Protexin® were elevated (p<0.05). In males fed additives liver weight was lighter than control group (p<0.05). In females fed Fermacto® and Protexin® + Fermacto® liver weight was reduced (p<0.05). Insulin level increased (p<0.05) by feeding of Fermacto and Protexin®+ Fermacto® in female and males respectively. The level of thyroxin in females depressed by feed additive consumption (p<0.05). Growth hormone level was elevated by consuming of feed additives in female birds (p<0.05). It was concluded that consumption of each Fermacto® and Protexin®+ Fermacto® in quail's diet can improve growth performance values by increasing the feed intake and stimulating the insulin and growth hormone release.</p>