Modeling Persistence in Mesenchymal Cell Motility Using Explicit Fibers

Cell motility is central to a variety of fundamental processes ranging from cancer metastasis to immune responses, but it is still poorly understood in realistic native environments. Previous theoretical work has tended to focus on intracellular mechanisms or on small pieces of interaction with the environment. In this article, we present a simulation which accounts for mesenchymal movement in a 3D environment with explicit collagen fibers and...