A low Wells score and a negative D-dimer was not safe in patients with cancer for ruling out DVT

In combination with a D-dimer serum test, the Wells rule has long been used and recommended to help clinicians discern the likelihood of lower extremity deep vein thrombosis (DVT).1 The safety and efficacy of these tools have been challenged in their applications to populations with distinct incidences of DVT.2 Specifically, patients with a prior DVT and those with malignancy have a high rate of venous thromboembolism (VTE) which may foreseeably...