Hydroxychloroquine and Surfactant Protein C Deficiency

To the Editor: We wish to report initial success in treating a boy with surfactant protein C deficiency. The patient was first admitted to the hospital at five months of age with severe respiratory distress that followed a viral respiratory infection. Open-lung biopsy revealed nonspecific interstitial pneumonitis, and DNA analysis revealed that the gene encoding surfactant protein C had a C-to-A substitution leading to an alanine-to-aspartate...