Abstract LB-468: miR-345 downregulation is associated with apoptosis resistance in pancreatic cancer: therapeutic implications

Resistance to apoptosis is one of the mechanisms underlying the highly metastatic and drug-resistant nature of pancreatic malignancy, which currently stands as the fourth leading cause of cancer-related death. Recent studies have identified several differentially-expressed microRNAs in pancreatic cancer, including miR-345, which is among the top aberrantly-expressed genes exhibiting significant downregulation. In this study, we have investigated...