Improvement of water saturation shift referencing by sequence and analysis optimization to enhance chemical exchange saturation transfer imaging

To optimize B0-field inhomogeneity correction for chemical exchange saturation transfer (CEST) imaging by investigating different water saturation shift referencing (WASSR) Z-spectrum shapes and different frequency correction techniques. WASSR Z-spectra were simulated for different B1-fields and pulse durations (PD). Two parameter settings were used for further simulations and experiments (WASSR1: B1 = 0.1 μT, PD = 50 ms; WASSR2: B1 = 0.3 μT, PD...