The popliteal lymph node assay in mice: screening of drugs and other chemicals for immunotoxic hazard.
Abstract
The popliteal lymph node assay (PLNA) in mice represents a predictive test for assessing the sensitizing (allergenic and autoimmunogenic) potential of drugs and low molecular weight chemicals. Measuring activation of the draining lymph node of the hind paw, the PLNA facilitates the detection and analysis of immunotoxic effects in a rapid and reproducible manner. An attractive feature of the PLNA is that it can be performed in combination with...
Paper Details
Title
The popliteal lymph node assay in mice: screening of drugs and other chemicals for immunotoxic hazard.
Published Date
Dec 1, 1996
Journal
Volume
45 Suppl 2
Pages
S85 - 90
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