Rising trend in vitamin D status from 1993 to 2013: dual concerns for the future.

Published on Sep 1, 2015in Endocrine connections3.335
· DOI :10.1530/EC-15-0037
Malachi J. McKenna29
Estimated H-index: 29
,
Barbara Murray12
Estimated H-index: 12
+ 1 AuthorsMark Kilbane13
Estimated H-index: 13
Sources
Abstract
Background The Institute of Medicine 2011 Report on Dietary Reference Intakes for Calcium and Vitamin D specified higher intakes for all age groups compared to the 1997 report, but also cautioned against spurious claims about an epidemic of vitamin D deficiency and against advocates of higher intake requirements. Over 40 years, we have noted marked improvement in vitamin D status but we are concerned about hypervitaminosis D.
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References45
Newest
#1Susan J. Whiting (U of S: University of Saskatchewan)H-Index: 61
Last. Brigitte RousseauH-Index: 7
view all 4 authors...
There is controversy surrounding the designation of vitamin D adequacy as defined by circulating levels of the metabolite 25-hydroxyvitamin D (25(OH)D). Depending on the cutoff level chosen, dietary intakes of vitamin D may or may not provide sufficient impact upon vitamin D status measured as improvement in serum levels of 25(OH)D. We sought to examine whether modest daily doses (5–20 μg) as found in fortified foods or multivitamin supplements had a measureable impact on vitamin D status, defin...
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#1Roger M. Francis (Newcastle University)H-Index: 60
#2Terry J. Aspray (Newcastle University)H-Index: 18
Last. N Tanna (London North West Healthcare NHS Trust)H-Index: 2
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Background: The vitamin D–endocrine system is thought to play a role in physiologic processes that range from mineral metabolism to immune function. Serum 25-hydroxyvitamin D [25(OH)D] is the accepted biomarker for vitamin D status. Skin color is a key determinant of circulating 25(OH)D concentrations, and genes responsible for melanin content have been shown to be under strong evolutionary selection in populations living in temperate zones. Little is known about the effect of latitude on mean c...
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For a number of years it has been widely assumed that measurement of serum 25-hydroxyvitamin D [25(OH)D] concentration is the best approach to assessing an individual's vitamin D status.[1, 2] However, it has also been recognized that there is substantial within-assay variation in 25(OH)D measurement and even greater between-assay variability.[3-5] Such assay variation clearly confounds attempts to define what constitutes the diagnosis of hypovitaminosis D. Importantly, assay variability makes p...
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#1Mark KilbaneH-Index: 13
#2Myra O'KeaneH-Index: 6
Last. Malachi J. McKenna (UCD: University College Dublin)H-Index: 29
view all 5 authors...
Introduction The Institute of Medicine (IOM) 2011 on dietary references intakes for calcium and vitamin D specified that a 25-hydroxyvitamin D (25OHD) level below 30 nmol/L indicated risk of deficiency and that a level above 125 nmol/L indicated risk of harm.
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#1Rajiv Chowdhury (University of Cambridge)H-Index: 62
#2Setor K Kunutsor (University of Cambridge)H-Index: 47
Last. Oscar H. Franco (EUR: Erasmus University Rotterdam)H-Index: 120
view all 16 authors...
Objective To evaluate the extent to which circulating biomarker and supplements of vitamin D are associated with mortality from cardiovascular, cancer, or other conditions, under various circumstances.
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#1Mark J Bolland (University of Auckland)H-Index: 60
#2Andrew Grey (University of Auckland)H-Index: 72
Last. Ian R. Reid (University of Auckland)H-Index: 124
view all 4 authors...
Summary Background Vitamin D insufficiency is associated with many disorders, leading to calls for widespread supplementation. Some investigators suggest that more clinical trials to test the effect of vitamin D on disorders are needed. Methods We did a trial sequential meta-analysis of existing randomised controlled trials of vitamin D supplements, with or without calcium, to investigate the possible effect of future trials on current knowledge. We estimated the effects of vitamin D supplementa...
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#1Evropi Theodoratou (Edin.: University of Edinburgh)H-Index: 62
#2Ioanna Tzoulaki (ICL: Imperial College London)H-Index: 72
Last. John P. A. Ioannidis (Stanford University)H-Index: 205
view all 4 authors...
Objective To evaluate the breadth, validity, and presence of biases of the associations of vitamin D with diverse outcomes.
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#1Maria G. Vogiatzi (Cornell University)H-Index: 19
#2Elka Jacobson-Dickman (SUNY Downstate Medical Center)H-Index: 7
Last. Mark D. DeBoer (University of Virginia Health System)H-Index: 43
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Context: Although vitamin D toxicity is rare in children, increased use of vitamin D formulations, re-examination of optimal vitamin D levels, and use of higher doses lend potential for an increased incidence of vitamin D toxicity. Evidence Acquisition: A PubMed search was conducted through May 2013 for cases of vitamin D intoxication and vitamin D trials in pediatrics. Safety data were collected and reviewed. Evidence Synthesis: A small number of pediatric studies tested vitamin D doses at or a...
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#1Ian R. Reid (University of Auckland)H-Index: 124
#2Mark J Bolland (University of Auckland)H-Index: 60
Last. Andrew Grey (University of Auckland)H-Index: 72
view all 3 authors...
Summary Background Findings from recent meta-analyses of vitamin D supplementation without co-administration of calcium have not shown fracture prevention, possibly because of insufficient power or inappropriate doses, or because the intervention was not targeted to deficient populations. Despite these data, almost half of older adults (older than 50 years) continue to use these supplements. Bone mineral density can be used to detect biologically significant effects in much smaller cohorts. We i...
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#1Helga H. HektoenH-Index: 3
#2Trude Eid RobsahmH-Index: 27
Last. Bettina Kulle AndreassenH-Index: 13
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BACKGROUND High circulating levels of vitamin D (25(OH)D) are suggested to reduce the risk of urinary bladder cancer (BC), but the evidence is weak, and several studies lack sufficient adjustment for potential confounders (e.g., smoking, body mass index (BMI), and physical activity). Moreover, few studies have investigated the role of vitamin D-binding protein (DBP) in this context. We conducted a matched nested case-control study including 378 cases and 378 controls within the Norwegian populat...
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#1E. C. O’Brien (UCD: University College Dublin)H-Index: 2
#2Aisling A. Geraghty (UCD: University College Dublin)H-Index: 10
Last. Fionnuala M. McAuliffe (UCD: University College Dublin)H-Index: 58
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BACKGROUND Pregnancy is characterized by increased bone turnover and reversible loss of bone mineral density (BMD) to meet fetal calcium demands. The long-term effect of bone turnover and maternal diet in pregnancy on maternal bone is not well established. OBJECTIVE We aimed to determine if an association exists between [1] bone resorption, [2] dietary calcium, and [3] serum 25-hydroxyvitamin D in pregnancy with maternal BMD 5-year postpartum. DESIGN This is a prospective, longitudinal study of ...
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#1Eva Summerhays (Umeå University)H-Index: 1
#2Mats Eliasson (Umeå University)H-Index: 54
Last. Viktor Oskarsson (Umeå University)H-Index: 9
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Purpose Vitamin D, produced through cutaneous photosynthesis or ingested via foods or supplements, has generated considerable research interest due to its potential health effects. However, epidemiological data on the time trends of vitamin D status are sparse, especially from northern Europe. We examined the time trend of vitamin D concentrations in northern Sweden between 1986 and 2014.
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#1Maeve Smith (UCD: University College Dublin)H-Index: 1
#2Eileen C O'Brien (UCD: University College Dublin)H-Index: 10
Last. Fionnuala M. McAuliffe (UCD: University College Dublin)H-Index: 58
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Background Vitamin D status may play a role in the development of atopic diseases due to its action on lung development and immune system development and function.
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#1Veronica Tsin Fong Voo (University of Melbourne)H-Index: 1
#2Jim StankovichH-Index: 40
Last. Mastura MonifH-Index: 12
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Objectives To investigate whether sex, age, medical specialty and seasonal variations in serum concentration of 25-hydroxy vitamin D (25(OH)D) are evident among an Australian patient population. Design Retrospective study analysing the results of serum 25(OH)D lab tests and vitamin D supplementation from Royal Melbourne Hospital (RMH) between 2014 and 2017. Setting Tertiary healthcare centre in Victoria, Australia. Participants 30 023 patients (inpatient and outpatient) who had their serum 25(OH...
Source
#1Nishant Raizada (AIIMS: All India Institute of Medical Sciences)H-Index: 4
#2Alpesh Goyal (AIIMS: All India Institute of Medical Sciences)H-Index: 6
Last. Rajesh Khadgawat (AIIMS: All India Institute of Medical Sciences)H-Index: 22
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Background: Serum 25-hydroxyvitamin D (25(OH)D) assays have become readily available in India over the past decade. A large number of cross-sectional studies have been performed on the vitamin D status and the prevalence of vitamin D deficiency (VDD) in India. However, seasonal and long-term trends in serum 25(OH)D levels have been reported less frequently. Aim: To determine the seasonal and year-wise variation in vitamin D status at a tertiary care hospital in north India. Materials and Methods...
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#1Shaima Sirajudeen (United Arab Emirates University)H-Index: 1
#2Iltaf Shah (United Arab Emirates University)H-Index: 15
Last. Asma Al Menhali (United Arab Emirates University)H-Index: 3
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Vitamin D is a major steroid hormone that is gaining attention as a therapeutic molecule. Due to the general awareness of its importance for the overall well-being, vitamin D deficiency (VDD) is now recognized as a major health issue. The main reason for VDD is minimal exposure to sunlight. The vitamin D receptor (VDR) is a member of the steroid hormone receptors that induces a cascade of cell signaling to maintain healthy Ca2+ levels that serve to regulate several biological functions. However,...
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#1Malachi J. McKenna (UCD: University College Dublin)H-Index: 29
#2Barbara MurrayH-Index: 12
Last. Mark KilbaneH-Index: 13
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Abstract Serum 25-hydroxyvitamin D (25OHD) is the pre-eminent estimate of vitamin D status that we have been measuring in a hospital laboratory setting since the 1970s. We previously evaluated the trend in 25OHD results in our laboratory from 1993 to 2013. Using a time series analysis of monthly average 25OHD results the trend was modelled, and this was used to forecast monthly average 25OHD from 2014 to 2016. In this study, all 25OHD results from 2014 to 2016 were retrieved (n = 67,922) and tri...
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#1Celia Rodd (UM: University of Manitoba)H-Index: 24
#2AbdulRazaq Sokoro (UM: University of Manitoba)H-Index: 7
Last. Eric Bohm (UM: University of Manitoba)H-Index: 26
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Abstract Introduction Laboratories have noted marked increases in the analysis of 25-hydroxy vitamin D (25(OH)D) in recent decades. Our objectives were to describe the annual number of 25(OH)D tests, examine the characteristics of those tested and those ordering them, and determine the proportion of potentially unnecessary tests in Manitoba. Methods Manitoba residents who were tested between 2006/7 and 2012/13 had their data anonymously linked to Manitoba Centre for Health Policy comprehensive a...
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#1Cagri CakiciH-Index: 1
#2Turkan Yigitbasi (Istanbul Medipol University)H-Index: 8
Last. Nesrin EmekliH-Index: 11
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: Background The purpose of this study is to examine the dose-dependent effects of vitamin 1,25(OH)2D3 on apoptosis and oxidative stress. Methods In this study, 50 male Balb/c mice were used as control and experiment groups. The mice were divided into 5 groups each consisting of 10 mice. Calcitriol was intraperitoneally administered as low dose, medium dose, medium-high dose and high dose vitamin D groups (at 0.5, 1, 5 and 10 μg/kg, respectively), for three times a week during 14 days. At the en...
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