Endocrine connections
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#1Xun Gong (SYSU: Sun Yat-sen University)
#2Lili You (SYSU: Sun Yat-sen University)H-Index: 1
Last. Guojuan Lao (SYSU: Sun Yat-sen University)H-Index: 9
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Objective Adiponectin is an adipocyte-derived hormone with an important role in glucose metabolism. The present study explored the effect of adiponectin in diverse population groups on pre-diabetes and newly diagnosed diabetes. Methods A total of 3300 individuals were enrolled and their data were collected in the analyses dataset from December 2018 to October 2019. Cluster analysis was conducted based on age, BMI, waistline, body fat, systolic blood pressure, triglycerides, and glycosylated hemo...
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#1Hong Jiang (SJTU: Shanghai Jiao Tong University)H-Index: 20
#2Wen-Jie Yang (SJTU: Shanghai Jiao Tong University)H-Index: 1
Last. Liuguan Bian (SJTU: Shanghai Jiao Tong University)H-Index: 16
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The adverse effects of hypercortisolism on the human brain have been highlighted in previous studies of Cushing's disease (CD). However, the relative alterations in regional hypercortisolism in the brain remain unclear. Thus, we investigated regional volumetric alterations in CD patients. We also analyzed the associations between these volumetric changes and clinical characteristics. The study participants comprised of active CD (n = 60), short-term-remitted CD (n = 28), and long-term-remitted C...
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#1Marek Niedziela (Poznan University of Medical Sciences)H-Index: 18
The term 'hyperthyroidism' refers to a form of thyrotoxicosis due to inappropriately high synthesis and secretion of thyroid hormone(s) by the thyroid. The leading cause of hyperthyroidism in adolescents is Graves' disease (GD); however, one should also consider other potential causes, such as toxic nodular goiter (single or multinodular) and other rare disorders leading to excessive production and release of thyroid hormones. The term 'thyrotoxicosis' refers to a clinical state resulting from i...
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#1João Castro-Teles (University of Porto)
#2Bernardo Sousa-Pinto (University of Porto)H-Index: 12
Last. Duarte PignatelliH-Index: 23
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Objective Pheochromocytomas are a hallmark feature of von Hippel-Lindau disease (vHL). To our knowledge, this is the first systematic review with meta-analysis evaluating the frequency of pheochromocytomas and/or paragangliomas (PPGLs) in patients with vHL, as well as among patients with different vHL subtypes. Design Systematic review with meta-analysis. Methods We searched on MEDLINE, Scopus, and Web of Science. We included primary studies assessing participants with vHL and reporting on the f...
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#1Qiuyu Huang (Fujian Medical University)H-Index: 2
#2Hanshen Chen (Fujian Medical University)
Last. Liang-Wan Chen (Fujian Medical University)H-Index: 11
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Type 2 diabetes mellitus (T2DM) is considered as a metabolic disease with hyperglycemia. Accumulating investigations have explored the important role of hereditary factors for T2DM occurrence. Some functional microRNA (miR) polymorphisms may affect their interactions with target mRNAs and result in an aberrant expression. Thus, miR-variants might be considered as a biomarker of the susceptibility of T2DM. In this study, we recruited 502 T2DM cases and 782 healthy subjects. We selected miR-146a r...
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#1Chun-feng Lu (Nantong University)
#2Wang-shu Liu (Nantong University)H-Index: 1
Last. Yan Wang (Nantong University)
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BACKGROUND Adenosine deaminase (ADA) is essential for the differentiation and maturation of lymphocytes, while lymphocytes infiltration in thyroid tissue is a vital pathological feature of Graves' disease (GD). The aim of the present study was to compare the concentration of ADA between healthy controls (HC) and patients with GD, and evaluate the association between ADA and GD. METHODS A total of 112 GD patients and 77 matched HC were enrolled in this study. Each participant was examined for thy...
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#1Mei Li (Guangxi Medical University)
#2Yanfei Chen (Guangxi Medical University)
Last. Dan Lan (Guangxi Medical University)
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OBJECTIVE To evaluate the characteristics and significance of serum kisspeptin and MKRN3 levels for the diagnostic of central precocious puberty (CPP) in girls. METHOD 34 individuals with CPP, 17 individuals with premature thelarche (PT) and 28 age-matched prepubertal girls as normal control (NC) were recruited in this case-control study. Physical measurements included of body mass index and tests for breast, bone and sexual characteristics were carried out. Biochemical measurements included ser...
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#1Sidsel Mathiesen (UCPH: University of Copenhagen)H-Index: 2
#2Kaspar Sørensen (UCPH: University of Copenhagen)H-Index: 30
Last. Klaus Müller (UCPH: University of Copenhagen)H-Index: 21
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Objectives Longitudinal assessment of testicular function after pediatric hematopoietic stem cell transplantation (HSCT) is needed to guide clinical follow-up. We investigated dynamics in male reproductive hormones after pediatric HSCT, focusing on pubertal timing and associations with testosterone deficiency and azoospermia in adulthood. Methods This retrospective, longitudinal study included 39 survivors median 19 years after pediatric HSCT. Serum concentrations of LH, testosterone, FSH, and i...
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#2Peter WolfH-Index: 12
Last. Philippe ChansonH-Index: 94
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Context null Measurement of IGF-I is important in the management of patients with growth hormone disorders. Here we aim to establish normative data for two new IGF-I assay kits based on a large random sample of the French general adult population. null Subjects and methods null We measured IGF-I in 911 healthy adults (18-90 years) with two immunoassays (ROCHE Elecsys® and IMMULITE-2000 calibrated against the new IS 02/2547). We compared the data with those of the six immunoassays (iSYS, LIAISON ...
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#1Sarmistha Banerjee (UPenn: University of Pennsylvania)H-Index: 10
#2Allison M. Hayes (UPenn: University of Pennsylvania)
Last. Bernard H. Shapiro (UPenn: University of Pennsylvania)H-Index: 29
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The sexually dimorphic expression of cytochromes P450 (CYP) drug metabolizing enzymes has been reported in all species examined. These sex differences are initially expressed during puberty and are solely regulated by sex differences in the circulating growth hormone (GH) profiles. Once established, however, the different male- and female-dependent CYP isoforms are permanent and immutable, suggesting that adult CYP expression requires imprinting. Since the hormone that regulates an adult functio...
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