New Insights into the Biosynthetic Logic of Ribosomally Synthesized and Post-translationally Modified Peptide Natural Products

•RiPPs provide an excellent platform to uncover unusual chemistry•The activities associated with RiPPs make them useful therapeutic molecules•Structural studies have started to uncover mechanisms of substrate recognition•Many novel RiPPs await discovery via genome-mining approaches Ribosomally synthesized and post-translationally modified peptides (RiPPs) are a large group of structurally diverse natural products. Their biological activities and...