Original paper
Rational design and diversity-oriented synthesis of peptoid-based selective HDAC6 inhibitors
Abstract
A mini library of HDAC inhibitors with peptoid-based cap groups was synthesized using an efficient multicomponent approach. Four compounds were identified as potent HDAC6 inhibitors with a selectivity over other HDAC isoforms. The most potent HDAC6 inhibitor revealed remarkable chemosensitizing properties and completely reverted the cisplatin resistance in Cal27 CisR...
Paper Details
Title
Rational design and diversity-oriented synthesis of peptoid-based selective HDAC6 inhibitors
Published Date
Jan 1, 2016
Journal
Volume
52
Issue
15
Pages
3219 - 3222
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Notes
History