Review paper
Critical Function of γH2A in S-Phase
Abstract
Phosphorylation of histone H2AX by ATM and ATR establishes a chromatin recruitment platform for DNA damage response proteins. Phospho-H2AX (γH2AX) has been most intensively studied in the context of DNA double-strand breaks caused by exogenous clastogens, but recent studies suggest that DNA replication stress also triggers formation of γH2A (ortholog of γH2AX) in Schizosaccharomyces pombe. Here, a focused genetic screen in fission yeast reveals...
Paper Details
Title
Critical Function of γH2A in S-Phase
Published Date
Sep 14, 2015
Journal
Volume
11
Issue
9
Pages
e1005517 - e1005517
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