Letter: smoking as a modifiable risk factor for a complicated course in Crohn's disease.

Published on Feb 1, 2016in Alimentary Pharmacology & Therapeutics7.515
· DOI :10.1111/APT.13476
N. To7
Estimated H-index: 7
(University of Leeds),
David J. Gracie16
Estimated H-index: 16
(University of Leeds),
Alexander C. Ford86
Estimated H-index: 86
(University of Leeds)
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Abstract
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SummaryBackground The detrimental effect of smoking on development and progression of Crohn's disease (CD) is generally accepted. Aim To evaluate the awareness of smoking risks in a Belgian inflammatory bowel disease (IBD) population. Methods In the out-patient clinic of a tertiary referral centre, 625 consecutive patients with CD, 238 patients with ulcerative colitis (UC) and 289 non-IBD controls, filled out a simple questionnaire. This questionnaire included data on smoking behaviour and aware...
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OBJECTIVES:Patients with Crohn’s disease (CD) who smoke are at a higher risk of flaring and requiring surgery. Cost-effectiveness studies of funding smoking cessation programs are lacking. Thus, we performed a cost–utility analysis of funding smoking cessation programs for CD.METHODS:A cost–utility
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#1Frans van der Heide (UMCG: University Medical Center Groningen)H-Index: 10
#2Marrit WassenaarH-Index: 1
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Objective Smoking is detrimental for Crohn's disease (CD), but beneficial for ulcerative colitis (UC). Earlier, we studied the effects of active and passive smoking in CD and UC patients from a university hospital. This study was conducted to assess the same effects in patients from a regional hospital. Methods A questionnaire focusing on cigarette smoke exposure was sent to 382 patients. Returned questionnaires (84%: 128 CD and 192 UC patients) were incorporated into a retrospective chart revie...
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#1Odes Hs (Soroka Medical Center)H-Index: 11
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Cigarette smoking worsens Crohn's disease (CD) but ameliorates ulcerative colitis (UC). In Israel, where there is no epidemiological association of smoking with CD, we examined the effects of current smoking on the course of CD and UC. Patients at nine public hospitals completed a questionnaire detailing their smoking history, disease course and treatments; subjects altering their smoking habit after the onset of disease were excluded. Sixty-four smokers and 144 nonsmokers had CD, and 34 smokers...
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Background : Cigarette smoking is associated with a more severe course of Crohn’s disease, but individual factors determining this effect are poorly known and it is not clear whether smoking cessation is associated with an improvement in the disease activity. Aim : To assess the factors determining the harmful effect of smoking in individuals with Crohn’s disease. Methods : A total of 622 consecutive patients with Crohn’s disease and Crohn’s disease activity index <200 were enrolled in a prospec...
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Abstract Background & Aims: Lifestyle factors have been shown to influence prognosis in Crohn's disease. The purpose of this study was to prospectively assess the effects of smoking and oral contraceptive use on clinical relapse rates. Methods: Placebo-treated patients formed a prospective cohort, followed up for 48 weeks or until relapse. The influence of smoking and the use of oral contraceptives on relapse risk was examined by life-table analysis (log rank tests) and Cox proportional hazards ...
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Objective: To evaluate the influence of regular smoking on the presentation and clinical course of inflammatory bowel disease. Methods: We performed a case-control study interviewing 160 inflammatory bowel disease patients (63 with Crohn's disease (CD) and 97 with ulcerative colitis (UC)) and 140 first-degree relatives as controls. The risk of developing the disease relative to a smoking habit was calculated as the odds ratio. Furthermore, to evaluate the influence of smoking on the subsequent c...
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In a case-control study 82 patients with Crohn9s disease and matched controls drawn from general practice lists were questioned about their smoking habits. Patients with Crohn9s disease were significantly more likely to be smokers than the controls, and the association was stronger for smoking habit before the onset of the disease than for current smoking habit, the relative risks for smokers compared with non-smokers being 4.8 and 3.5 respectively. Taken in conjunction with earlier data showing...
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#2Marc Ferrante (Katholieke Universiteit Leuven)H-Index: 59
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