Original paper
MEF 2 and NR 2F2 cooperate to regulate Akr1c14 gene expression in mouse MA ‐10 Leydig cells
Abstract
Leydig cells are essential for male reproductive development and health throughout life. Production of androgens [testosterone, dihydrotestosterone (DHT)] as well as intermediate steroids [progesterone, dihydroprogesterone (DHP)] is tightly regulated. In the mouse, the 3α-hydroxysteroid dehydrogenase enzyme (3α-HSD, AKR1C14) catalyses the interconversion of DHP and DHT into less potent steroids. Despite its importance, nothing is currently known...
Paper Details
Title
Published Date
Jan 8, 2016
Journal
Volume
4
Issue
2
Pages
335 - 344
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Notes
History