VAMP2–NRG1 Fusion Gene is a Novel Oncogenic Driver of Non–Small-Cell Lung Adenocarcinoma

Introduction:Neuregulin 1 (NRG1) has been discovered as the tail moiety of fusion genes with several distinct partner head genes in lung cancers. These fusion genes activate ERBB2/ERBB3 receptor-mediated cell signaling and thereby function as oncogenic drivers.Methods:We have carried out whole-transcriptome sequencing of 100 non–small-cell lung carcinoma tumors and isolated a novel fusion gene consisting of vesicle-associated membrane protein 2...