Nitric Oxide (NO) can autoregulate its own formation by feedback inhibition of the inducible Nitric Oxide Synthase (iNOS). Modulation of biosynthesis or activity of NO results in amelioration if pathogenesis of experimental arthritis. However, little is known about feedback mechanism on NO generation in response to carrageenan induced paw oedema and adjuvant- induced arthritis. In the present study we have examined the effects of prophylactic administration of extracts of bark of Sesbania grandiflora and Sesbania sesban on the development of carrageenan induced paw oedema and adjuvant - induced arthritis to assess influence of high NO level in the form of exogenous herbal extracts of bark of Sesbania grandiflora and Sesbania sesban in the progress of inflammation. Inflammation was assessed by measuring paw swelling. Increased paw oedema of the injected paw measured on 1 st to 12 th hrs which is feature of carrageenan induced inflammation was significantly reduced after prophylactic administration of petroleum...

Medicine

Chemistry

Pharmacology

Traditional medicine

Inflammation

Arthritis

Broiler

Sesbania

Sesbania sesban

Effect of Sesbania grandiflora and Sesbania sesban bark on carrageenan induced acute inflammation and adjuvant-induced arthritis in rats.