Review paper
Antibody Drug Conjugates for Cancer Therapy
Abstract
Antibody drug conjugates (ADCs) constitute a family of cancer therapeutics designed to preferentially direct a cytotoxic drug to cells expressing a cell-surface antigen recognized by an antibody. The antibody and drug are linked through chemistries that enable release of the cytotoxic drug or drug adduct upon internalization and digestion of the ADC by the cell. Over 40 distinct ADCs, targeting an array of antigens and utilizing a variety of...
Paper Details
Title
Antibody Drug Conjugates for Cancer Therapy
Published Date
Nov 20, 2015
Journal
Volume
68
Issue
1
Pages
3 - 19
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