Survey of the Literature for September 2015 Issue of Sexual Medicine Journal

Over the past decade we have begun to understand the molecular and genetic underpinnings of Peyronie's disease (PD). We now know that the transforming growth factor (TGF)-β signaling pathway is one of the major contributors to aberrant fibrosis in PD, and are beginning to understand that other pathways, including the Wnt/β-catenin and mitogen-activated protein kinase pathways may also be involved [1]. Our understanding of genetic factors that...