Cerebral cavernous malformations proteins inhibit Rho kinase to stabilize vascular integrity
Abstract
Endothelial cell-cell junctions regulate vascular permeability, vasculogenesis, and angiogenesis. Familial cerebral cavernous malformations (CCMs) in humans result from mutations of CCM2 (malcavernin, OSM, MGC4607), PDCD10 (CCM3), or KRIT1 (CCM1), a Rap1 effector which stabilizes endothelial cell-cell junctions. Homozygous loss of KRIT1 or CCM2 produces lethal vascular phenotypes in mice and zebrafish. We report that the physical interaction of...
Paper Details
Title
Cerebral cavernous malformations proteins inhibit Rho kinase to stabilize vascular integrity
Published Date
Mar 22, 2010
Volume
207
Issue
4
Pages
881 - 896
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