Substance P Enhances Wound Closure in Nitric Oxide Synthase Knockout Mice
Abstract
The neuropeptide, substance P (SP), up-regulates nitric oxide production (NO). The purpose of this study was to determine whether SP enhances response to cutaneous injury in nitric oxide synthase knockout (NOS null) mice.We studied mice with targeted deletions of the 3 NOS genes, neuronal NOS, inducible NOS, or endothelial NOS. Full thickness dorsal wounds were treated daily (d 0-6) with topical SP or normal saline (NaCl). Wounds were analyzed...
Paper Details
Title
Substance P Enhances Wound Closure in Nitric Oxide Synthase Knockout Mice
Published Date
May 1, 2009
Journal
Volume
153
Issue
2
Pages
201 - 209
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