Hypogonadism or Testosterone Deficiency (TD) in adult men as defined by low levels of serum testosterone accompanied by characteristic symptoms and/or signs as detailed further on can be found in long-recognized clinical entities such as Klinefelter syndrome, Kallmann syndrome, pituitary or testicular disorders, as well as in men with idiopathic, metabolic or iatrogenic conditions that result in testosterone deficiency. These recommendations do not encompass the full range of pathologies leading to hypogonadism (testosterone deficiency), but instead focus on the clinical spectrum of hypogonadism related to metabolic and idiopathic disorders that contribute to the majority of cases that occur in adult men.
Objective To investigate the association between hypogonadal symptoms and serum total testosterone (TT) levels in young men (aged <40 years), in an attempt to determine whether there exists a clear-cut discriminatory threshold of TT below which hypogonadal symptoms become more prevalent. Patients and methods We retrospectively reviewed the charts of 352 men who presented to an outpatient Men's Health Clinic with chief complaint of ‘low testosterone’. Sexual, psychological and physical symptoms w...
Last. Aksam Yassin(Gulf Medical University)H-Index: 29
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Purpose: Although there is no evidence that testosterone therapy increases the risk of prostate cancer, there is a paucity of long-term data. We determined whether the incidence of prostate cancer is increased in hypogonadal men receiving long-term testosterone therapy.Materials and Methods: In 3 parallel, prospective, ongoing, cumulative registry studies 1,023 hypogonadal men received testosterone therapy. Two study cohorts were treated by urologists (since 2004) and 1 was treated at an academi...
Abstract Introduction Factors influencing prostate‐specific antigen (PSA) changes in men undergoing testosterone (T) therapy have not been well studied. Aim The aim of this study was to assess the influence of selected variables on PSA changes in hypogonadal men administered with 1.62% testosterone gel (T‐gel) for 6 months. Methods A double‐blind, placebo‐controlled study of 274 (234 T‐gel, 40 placebo) hypogonadal men >18 years of age, with baseline T concentrations Main Outcome Measures Changes...
#2Elisa Maseroli(UniFI: University of Florence)H-Index: 25
Last. Mario Maggi(UniFI: University of Florence)H-Index: 160
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Introduction: Recent reports have significantly halted the enthusiasm regarding androgen-boosting; suggesting that testosterone supplementation (TS) increases cardiovascular (CV) events.Areas covered: In order to overcome some of the limitations of the current evidence, the authors performed an updated systematic review and meta-analysis of all placebo-controlled randomized clinical trials (RCTs) on the effect of TS on CV-related problems. Out of 2747 retrieved articles, 75 were analyzed, includ...
#2Louis J. Gooren(VUmc: VU University Medical Center)H-Index: 27
Abstract Some men between the ages 45 and 60 years develop complaints and symptoms reminiscent of menopausal complaints in women. So, parallels were sought between the changes in female and male endocrinology during that period of life. Indeed, men do show a decline of serum testosterone from age 40 to 50 years onwards but it is a slow decline of 1–2% per year and over time it may amount to hypogonadism. The mechanism of a decline in serum testosterone in men does not resemble the menopause; it ...
Purpose Many men with “late-onset hypogonadism” (LOH) experience lower urinary tract symptoms (LUTS) that can be distressing and may decrease quality of life. LUTS often appear in men when testosterone levels begin to decline, which could be a significant association. We investigated whether testosterone replacement could alleviate LUTS in men with LOH.
Abstract Introduction Despite increasing use of testosterone therapy (TTh) for men with testosterone deficiency (TD), there remains uncertainty determining who is a candidate for treatment. Aim The aim if this study was to report the opinions of international experts on TTh, as initially presented at the meeting of the World Meeting on Sexual Medicine in Chicago, United States in August 2012. Methods Expert responses to questions regarding the diagnosis of TD based on their own clinical and rese...
Last. Mario Maggi(UniFI: University of Florence)H-Index: 160
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Introduction. The role of testosterone supplementation (TS) as a treatment for male sexual dysfunction remains questionable. Aim. The aim of this study was to attempt a meta-analysis on the effect of TS on male sexual function and its synergism with the use of phosphodiesterase type 5 inhibitor (PDE5i). Methods. An extensive Medline, Embase, and Cochrane search was performed. Main Outcome Measures. All randomized controlled trials (RCTs) comparing the effect of TS vs. placebo or the effect of TS...
Last. Du Geon Moon(KU: Korea University)H-Index: 23
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Objectives To investigate the putative association between nocturia and decreased serum testosterone in men with lower urinary tract symptoms. Methods Frequency volume charts and serum testosterone levels of patients visiting the outpatient clinic for lower urinary tract symptoms were collected and analyzed. Age, prostate volume, body mass index and the presence of comorbidities were accounted for. Frequency volume charts were analyzed for pathophysiological components of nocturnal polyuria, glo...
Abstract null null Background null Though testosterone replacement therapy in men with organic hypogonadism is established, its role in men with type 2 diabetes mellitus (T2DM) and functional hypogonadism is unclear. null null null Methods null Thirteen experts addressed ten topic-specific questions after an in-depth review of literature, where all relevant issues were critically evaluated. null null null Results null Ten recommendations concerning diagnosis and management of men with T2DM and f...
Last. Jae Heon Kim(SCH: Soonchunhyang University)H-Index: 17
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PURPOSE Late onset hypogonadism (LOH) is an age-dependent reduction of testosterone associated with alterations of metabolic profile, including glucose control, insulin sensitivity, and lipid profile. The purpose of this study was to investigate the efficacy of testosterone replacement therapy (TRT) for treating metabolic disturbances through a meta-analysis of randomized clinical trials (RCTs). METHODS A systematic review of literature published from 1964 to November, 2019 was performed using t...
Last. Aurelia Nattiv(UCLA: University of California, Los Angeles)H-Index: 23
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ABSTRACT The Male Athlete Triad is a medical syndrome most common in adolescent and young adult male athletes in sports that emphasize a lean physique, especially endurance and weight-class athletes. The 3 interrelated conditions of the Male Athlete Triad occur on spectrums of energy deficiency/low energy availability (EA), suppression of the hypothalamic-pituitary-gonadal axis, and impaired bone health, ranging from optimal health to clinically relevant outcomes of energy deficiency/low EA with...
OBJECTIVES The Francophone Society of Sexual Medicine (SFMS) and the Andrology and Sexual Medicine Committee (CAMS) of the French Association of Urology (AFU) have brought together a panel of experts to develop French recommendations for the management of testosterone deficiency (TD). METHODS Systematic review of the literature between 01/2000 and 07/2019. Use of the method of recommendations for clinical practice (RPC) and the AGREE II grid. RESULTS TD is defined as the association of clinical ...
Last. A. V. Osadchuk(RAS: Russian Academy of Sciences)H-Index: 2
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BACKGROUND This is the first large-scale Russian study describing semen quality and reproductive hormone levels among young men. OBJECTIVES The aim of the study was to compare semen quality and reproductive hormone levels in young men of four cities and three ethnic groups living in the Siberian region of Russia and to find out ethnic or environmental reasons for regional differences. MATERIALS AND METHODS The study population consisted of 1,291 young men from Novosibirsk, Kemerovo, Ulan-Ude and...
#1Guoqing Liang(Tianjin Medical University General Hospital)
#2Yuxuan Song(Tianjin Medical University General Hospital)H-Index: 8
Last. Xiaoqiang Liu(Tianjin Medical University General Hospital)H-Index: 6
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Background To investigate whether serum levels of sex hormone-binding globulin (SHBG) and testosterone are associated with symptomatic late-onset hypogonadism (SLOH) in middle-aged and elderly rural Chinese males. Methods: A population-based cross-sectional study was conducted in Zhejiang rural communities. A total of 965 men (aged 40–80 years) were admitted to the aging males’ symptoms (AMS) scale and related physical examinations including body mass index (BMI) and waist circumference were con...
Resume Contexte Ces recommandations communes de l’Association Francaise d’Urologie (AFU) et de la Societe d’Andrologie de Langue Francaise (SALF) ont pour objectif de fournir des directives pratiques a la communaute urologique et andrologique Francaise concernant l’evaluation des hommes infertiles. Materiel et methodes Recherche bibliographique dans PubMed en utilisant les mots-cles «male infertility», «diagnosis», «management» et «evaluation» limitee aux articles cliniques en anglais et en fran...
The cardiovascular (CV) benefit and safety of treating low testosterone conditions is a matter of debate. Although testosterone deficiency has been linked to a rise in major adverse CV events, most of the studies on testosterone replacement therapy were not designed to assess CV risk and thus excluded men with advanced heart failure or recent history of myocardial infarction or stroke. Besides considering observational, interventional and prospective studies, this review article evaluates the im...
#1Guoqing Liang(Tianjin Medical University General Hospital)
#2Yuxuan Song(Tianjin Medical University General Hospital)H-Index: 8
Last. Xiaoqiang Liu(Tianjin Medical University General Hospital)H-Index: 6
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The association between hypogonadism symptoms and the levels of serum hormones are still in debate. To investigate the relationship between hypogonadism symptoms and serum hormones in middle-aged and elderly Chinese men, this community-based cross-sectional study was conducted based on a total of 965 ageing men. The ageing males' symptom (AMS) scale, International Index of Erectile Function-5 (IIEF-5), International Prostate Symptom Score (IPSS) questionnaires and related variables were assessed...
Bone fracture due to osteoporosis is an important issue in decreasing the quality of life for elderly men in the current aging society. Thus, osteoporosis and bone fracture prevention is a clinical concern for many clinicians. Moreover, testosterone has an important role in maintaining bone mineral density (BMD) among men. Some testosterone molecular mechanisms on bone metabolism have been currently established by many experimental data. Concurrent with a decrease in testosterone with age, vario...