Positron-emission tomography molecular imaging of glia and myelin in drug discovery for multiple sclerosis

Therapies acting on glial cells are being explored for new drug development for multiple sclerosis. Molecular imaging using positron-emission tomography (PET) could address relevant questions in early phase clinical trials.In this article, the authors critically review human PET methods that can be applied in specialised centres for imaging activated microglia and astrocytes and myelin.Strengths of PET lie in the molecular selectivity,...