Identification of dimer impurities in ampicillin and amoxicillin by capillary LC and tandem mass spectrometry
Abstract
A micro-scale liquid chromatography electrospray ionization tandem mass spectrometric method was developed for the identification of polymerized impurities in ampicillin and amoxicillin in aqueous solution. Ampicillin and amoxicillin are broad-spectrum antibiotics and widely used for the treatment of human and animal infections. In this study ampicillin, amoxicillin, and their dimers were trapped in a 5-cm capillary column containing C18...
Paper Details
Title
Identification of dimer impurities in ampicillin and amoxicillin by capillary LC and tandem mass spectrometry
Published Date
Feb 1, 2007
Volume
30
Issue
3
Pages
329 - 332
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