Evaluation of Hepatic Glutathione Transferase Mu 1 and Theta 1 Activities in Humans and Mice Using Genotype Information
Abstract
We investigated the impact of glutathione transferases Mu 1 (GSTM1)- and glutathione transferase Theta 1 (GSTT1)-null genotypes on hepatic GST activities in humans and compared the results with those of Gstm1- and Gstt1-null mice. In liver with GSTM1/Gstm1-null genotype, GST activity toward p-nitrobenzyl chloride (NBC) was significantly decreased in both humans and mice. In addition, in liver with...
Paper Details
Title
Evaluation of Hepatic Glutathione Transferase Mu 1 and Theta 1 Activities in Humans and Mice Using Genotype Information
Published Date
Dec 14, 2011
Volume
40
Issue
3
Pages
497 - 503
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