Sulforaphane has opposing effects on TNF-alpha stimulated and unstimulated synoviocytes
Abstract
Rheumatoid arthritis (RA) is characterized by progressive inflammation associated with rampantly proliferating synoviocytes and joint destruction due to oxidative stress. Recently, we described nuclear factor erythroid 2-related factor 2 (Nrf2) as a major requirement for limiting cartilage destruction. NF-κB and AP-1 are the main transcription factors triggering the inflammatory progression in RA. We used sulforaphane, an isothiocyanate, which...
Paper Details
Title
Sulforaphane has opposing effects on TNF-alpha stimulated and unstimulated synoviocytes
Published Date
Jan 1, 2012
Journal
Volume
14
Issue
5
Pages
R220 - R220
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Notes
History