Diabetes increases brain damage caused by severe hypoglycemia

Insulin-induced severe hypoglycemia causes brain damage. The hypothesis to be tested was that diabetes portends to more extensive brain tissue damage following an episode of severe hypoglycemia. Nine-week-old male streptozotocin-diabetic (DIAB; n = 10) or vehicle-injected control (CONT; n = 7) Sprague-Dawley rats were subjected to hyperinsulinemic (0.2 U·kg −1 ·min −1 ) severe hypoglycemic (10–15 mg/dl) clamps while awake and unrestrained....