Original paper
Distribution and intensity of constraint in mammalian genomic sequence
Abstract
Comparisons of orthologous genomic DNA sequences can be used to characterize regions that have been subject to purifying selection and are enriched for functional elements. We here present the results of such an analysis on an alignment of sequences from 29 mammalian species. The alignment captures ∼3.9 neutral substitutions per site and spans ∼1.9 Mbp of the human genome. We identify constrained elements from 3 bp to over 1 kbp in length,...
Paper Details
Title
Distribution and intensity of constraint in mammalian genomic sequence
Published Date
Jun 17, 2005
Journal
Volume
15
Issue
7
Pages
901 - 913
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Notes
History