Review paper
HPLC–Tandem Mass Spectrometric Method for Rapid Quantification of Dimethylarginines in Human Plasma
Abstract
Asymmetric dimethylarginine (ADMA) and symmetric dimethylarginine (SDMA) are derived from posttranslational methylation of arginine residues in proteins and after proteolytic release. Whereas protein methylation appears to be important in RNA binding and protein sorting, ADMA evolved as a competitive inhibitor of nitric oxide synthase at the arginine-binding site (1)(2). At a constant arginine supply, increased ADMA concentrations decrease NO...
Paper Details
Title
HPLC–Tandem Mass Spectrometric Method for Rapid Quantification of Dimethylarginines in Human Plasma
Published Date
Jan 1, 2005
Journal
Volume
51
Issue
1
Pages
249 - 252
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