Targeting of erbB3 receptor to overcome resistance in cancer treatment
Abstract
The erbB receptors, including the epidermal growth factor receptor (EGFR), erbB2 (also known as HER2/neu), erbB3 (or HER3), and erbB4 (or HER4), are often aberrantly activated in a wide variety of human cancers. They are excellent targets for selective anti-cancer therapies because of their transmembrane location and pro-oncogenic activity. While several therapeutic agents against erbB2 and/or EGFR have been used in the treatment of human...
Paper Details
Title
Targeting of erbB3 receptor to overcome resistance in cancer treatment
Published Date
May 8, 2014
Journal
Volume
13
Issue
1
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