OBJECTIVE. Early dynamic PET/CT is primarily used for oncologic perfusion studies. The purpose of this article is to show how the modality can be applied for angiography with data reconstructed in time-based frames for direct visualization of arterial vessels. CONCLUSION. Our initial data suggest that PET angiography can be used to establish patency and delineate relevant stenoses and occlusions. It therefore may be a useful complement to conventional angiography.
OBJECTIVE. The purpose of this study was to prospectively evaluate the average heart rate and heart rate variability required for diagnostic imaging of the coronary arteries with high-pitch dual-source CT angiography of the thoracic and thoracoabdominal aorta.SUBJECTS AND METHODS. One hundred consecutively registered patients (82 men, 18 women; mean age, 68 ± 13 years) underwent clinically indicated CT angiography of the thoracic (n = 33) and thoracoabdominal (n = 67) aorta with a dual-source 12...
#2Roy S. Herbst(University of Texas MD Anderson Cancer Center)H-Index: 109
Last. James L. Abbruzzese(University of Texas MD Anderson Cancer Center)H-Index: 134
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PET molecular imaging of 15 O-labeled water is the gold standard for measuring blood flow in humans. However, this requires an on-site cyclotron to produce the short-lived 15 O tracer, which is cost-prohibitive for most clinical PET centers. The purpose of this study was to determine if the early uptake of 18 F-FDG could be used to measure regional blood flow in tumors in the absence of 15 O-water. Methods: PET scans were obtained in patients being evaluated for tumor perfusion and glucose metab...
#1Robert F. Hanna(UCSD: University of California, San Diego)H-Index: 8
#2Norbert Kased(UCSD: University of California, San Diego)H-Index: 11
Last. Claude B. Sirlin(UCSD: University of California, San Diego)H-Index: 106
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OBJECTIVE. The aim of this study was to evaluate the accuracy of a double-contrast MRI protocol in staging of hepatocellular carcinoma (HCC) in patients with cirrhosis.MATERIALS AND METHODS. This cross-sectional study was performed at a tertiary liver care center. Forty-eight patients with cirrhosis underwent double-contrast MRI for clinical care and liver transplantation. For each MRI examination, superparamagnetic iron oxide was infused, and 2D T2*-weighted spoiled gradient-recalled echo and T...
Adverse reactions to intravenous iodinated contrast media may be classified as general and organ-specific, such as contrast-induced nephrotoxicity. General adverse reactions may be subclassified into acute and delayed types. Acute general adverse reactions can range from transient minor reactions to life-threatening severe reactions. Non-ionic contrast media have lower risk of mild and moderate adverse reactions. However, the risk of fatal reactions is similar for ionic and non-ionic contrast me...
OBJECTIVE. Our study was a prospective in vivo study to evaluate whether MR angiography is suitable for assessing stent patency and grading in-stent stenoses and to examine whether the accuracy of MR angiography changes with time after stent implantation.SUBJECTS AND METHODS. In a prospective study, 34 iliac stenoses in 27 patients were treated by implantation of 35 nitinol stents. MR angiography was performed immediately after stent placement for 32 stents, and both digital subtraction angiogra...
• Arterial visualization using the gamma camera was achieved by peripheral intravenous injection of technetium pertechnetate Tc 99m 253 times in 200 patients. This technique, which successfully images the arterial tree to the level of the wrist and ankle, was validated by blind comparison of the scintiangiograms with contrast arteriograms or surgical findings or both in 93 studies. Although scintiangiography has less resolution than contrast arteriography, it provides quantitative and other impo...
Tumor-associated vasculature is responsible for the delivery of nutrients, removal of waste, and allowing growth beyond 2–3 mm3. Additionally, the vascular network, which is changing in both space and time, fundamentally influences tumor response to both systemic and radiation therapy. Thus, a robust understanding of vascular dynamics is necessary to accurately predict tumor growth, as well as establish optimal treatment protocols to achieve optimal tumor control. Such a goal requires the intima...
A 61-year-old male patient with known kidney dysfunction who underwent a non-contrast thorax CT and was then referred to our department for metabolic assessment of solitary pulmonary nodule (SPN). The patient underwent dynamic FDG PET/CT to differentiate benign from malignant SPN. This case illustrates the usefulness of dynamic FDG PET/CT imaging when assessing SPN especially in patients with suspicion for pulmonary arterio-venous malformation accompanying renal failure or contrast allergy.
#2Senthil Selvaraj(UPenn: University of Pennsylvania)H-Index: 17
Last. Paco E Bravo(UPenn: University of Pennsylvania)H-Index: 5
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Cardiovascular conditions can exist as part of a systemic disorder (eg, sarcoidosis, amyloidosis, or vasculitis) or have systemic consequences as a result of the cardiovascular insult (eg, myocardial infarction). In other circumstances, multisystem evaluation of metabolism and blood flow might be key for evaluation of multisystemic syndromes or conditions. Long axial field-of-view PET/computed tomography systems hold the promise of transforming the investigation of such systemic disorders. This ...
PURPOSE: To propose a positron emission tomography (PET)/computed tomography (CT) protocol including early-dynamic and late-phase acquisitions to evaluate graft patency and aneurysm diameter, detect endoleaks, and rule out graft or vessel wall inflammation after endovascular aneurysm repair (EVAR) in one examination without intravenous contrast medium. TECHNIQUE: Early-dynamic PET/CT of the endovascular prosthesis is performed for 180 seconds immediately after intravenous injection of F-18-fluor...
Abstract Purpose The purpose was to show the feasibility of F-18 choline positron emission tomography (PET) angiography for the evaluation of abdominal and iliac arteries. Methods Thirty-five patients were examined and image quality was scored. Findings were correlated with contrast-enhanced computed tomography. Results Image quality was best in the aorta and common iliac arteries (100% and 93% of vessels). Negative predictive values of PET angiography were excellent (100%), and positive predict...
Objective Positron emission tomography (PET) angiography utilizes early dynamic PET acquisitions for depiction of the arterial vasculature. The aim of this study was to assess image quality and to evaluate feasibility of F-18 FDG PET angiography of the abdominal arteries.
Abstract Two patients with aortoiliac occlusive disease underwent dynamic and late-static positron emission tomography/computed tomography (PET/CT) acquisitions with 257 and 244 MBq F-18 FDG (CT scan parameters 50 mAs, 120 kV, pitch 1.25). Three-dimensional reconstructions revealed an occluded aortic stent and a high-grade aortic stenosis and demonstrated the relations of vascular pathologies to adjacent structures. Early-dynamic PET can be performed without additional radioactive tracer and may...