Original paper
Anti-inflammatory effects of a novel, potent inhibitor of poly (ADP-ribose) polymerase
Abstract
Objective and design: Oxygen- and nitrogen-derived free radicals and oxidants play an important role in the pathogenesis of various forms of inflammation. Recent work emphasizes the importance of oxidant-induced DNA strand breakage and activation of the nuclear enzyme poly(ADP-ribose) polymerase (PARP) in the pathogenesis of various inflammatory diseases. We have recently demonstrated the efficacy of PJ34, a novel, potent phenanthridinone...
Paper Details
Title
Anti-inflammatory effects of a novel, potent inhibitor of poly (ADP-ribose) polymerase
Published Date
Nov 1, 2001
Journal
Volume
50
Issue
11
Pages
561 - 569
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Notes
History