A synthetic hexapeptide (Argireline) with antiwrinkle activity

Synopsis Botulinum neurotoxins (BoNTs) represent a revolution in cosmetic science because of their remarkable and long‐lasting antiwrinkle activity. However, their high neurotoxicity seriously limits their use. Thus, there is a need to design and validate non‐toxic molecules that mimic the action of BoNTs. The hexapeptide Ac‐EEMQRR‐NH 2 (coined Argireline) was identified as a result of a rational design programme. Noteworthy, skin topography...