Review paper
Immune Checkpoint Blockade: A Common Denominator Approach to Cancer Therapy
Abstract
The immune system recognizes and is poised to eliminate cancer but is held in check by inhibitory receptors and ligands. These immune checkpoint pathways, which normally maintain self-tolerance and limit collateral tissue damage during anti-microbial immune responses, can be co-opted by cancer to evade immune destruction. Drugs interrupting immune checkpoints, such as anti-CTLA-4, anti-PD-1, anti-PD-L1, and others in early development, can...
Paper Details
Title
Immune Checkpoint Blockade: A Common Denominator Approach to Cancer Therapy
Published Date
Apr 1, 2015
Journal
Volume
27
Issue
4
Pages
450 - 461
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