Original paper
Potential Mechanisms for Thrombocytopenia Development with Trastuzumab Emtansine (T-DM1)
Abstract
Trastuzumab-emtansine (T-DM1) is an antibody-drug conjugate (ADC) comprising the cytotoxic agent DM1 conjugated to trastuzumab with a stable linker. Thrombocytopenia was the dose-limiting toxicity in the phase I study, and grade ≥3 thrombocytopenia occurred in up to 13% of patients receiving T-DM1 in phase III studies. We investigated the mechanism of T-DM1-induced thrombocytopenia.The effect of T-DM1 on platelet function was measured by...
Paper Details
Title
Potential Mechanisms for Thrombocytopenia Development with Trastuzumab Emtansine (T-DM1)
Published Date
Jan 1, 2015
Journal
Volume
21
Issue
1
Pages
123 - 133
Citation AnalysisPro
You’ll need to upgrade your plan to Pro
Looking to understand the true influence of a researcher’s work across journals & affiliations?
- Scinapse’s Top 10 Citation Journals & Affiliations graph reveals the quality and authenticity of citations received by a paper.
- Discover whether citations have been inflated due to self-citations, or if citations include institutional bias.
Notes
History