CYTOTOXICITY OF COLCHICINE DERIVATIVES IN PRIMARY CULTURES OF HUMAN HEPATOCYTES

Background: Colchicine has been used to treat gout for centuries. However, owing to its toxicity it displays a variety of side effects. The replacement of colchicine by less toxic but still active derivatives would solve this drawback. Aim: The aim of this study was to examine the cytotoxicity of 17 colchicine derivatives. Methods: Primary cultures of human hepatocytes were the model of choice. Prior to testing, we measured the biochemical...