The relationship between DNA methylation, genetic and expression inter-individual variation in untransformed human fibroblasts

DNA methylation plays an essential role in the regulation of gene expression. While its presence near the transcription start site of a gene has been associated with reduced expression, the variation in methylation levels across individuals, its environmental or genetic causes, and its association with gene expression remain poorly understood. We report the joint analysis of sequence variants, gene expression and DNA methylation in primary...