Original paper
Construction and Characterization of Novel, Completely Human Serine Protease Therapeutics Targeting Her2/neu
Abstract
Immunotoxins containing bacterial or plant toxins have shown promise in cancer-targeted therapy, but their long-term clinical use may be hampered by vascular leak syndrome and immunogenicity of the toxin. We incorporated human granzyme B (GrB) as an effector and generated completely human chimeric fusion proteins containing the humanized anti-Her2/neu single-chain antibody 4D5 (designated GrB/4D5). Introduction of a pH-sensitive fusogenic...
Paper Details
Title
Construction and Characterization of Novel, Completely Human Serine Protease Therapeutics Targeting Her2/neu
Published Date
Jun 1, 2013
Volume
12
Issue
6
Pages
979 - 991
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Notes
History