D-β-Hydroxybutyrate rescues mitochondrial respiration and mitigates features of Parkinson disease
Volume: 112, Issue: 6, Pages: 892 - 901
Published: Sep 15, 2003
Abstract
Parkinson disease (PD) is a neurodegenerative disorder characterized by a loss of the nigrostriatal dopaminergic neurons accompanied by a deficit in mitochondrial respiration. 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) is a neurotoxin that causes dopaminergic neurodegeneration and a mitochondrial deficit reminiscent of PD. Here we show that the infusion of the ketone body D-β-hydroxybutyrate (DβHB) in mice confers partial protection...
Paper Details
Title
D-β-Hydroxybutyrate rescues mitochondrial respiration and mitigates features of Parkinson disease
Published Date
Sep 15, 2003
Volume
112
Issue
6
Pages
892 - 901
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