Molecular Pathways: Targeting ATR in Cancer Therapy
Abstract
The human ATR gene encodes a kinase that is activated by DNA damage and replication stress as a central transducer of a checkpoint signaling pathway. Once activated, ATR phosphorylates multiple substrates, including the kinase Chk1, to regulate cell-cycle progression, replication fork stability, and DNA repair. These events promote cell survival during replication stress and in cells with DNA damage. Accordingly, there has been the tantalizing...
Paper Details
Title
Molecular Pathways: Targeting ATR in Cancer Therapy
Published Date
Nov 1, 2015
Journal
Volume
21
Issue
21
Pages
4780 - 4785
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