Activation of the α3 Integrin Affects TRAF6 Function In The IL-1 Signaling Pathway of CACO-2 Epithelial Cells

Intestinal epithelial cells express the alpha3beta1 integrin which binds to laminin-5. We have previously shown that activation of the alpha3 integrin through laminin-5 binding or a cross-linking antibody results in a suppression of IL-1 induced cytokine secretion and intracellular signaling through IKK to NF-kappaB and JNK to AP-1 in Caco-2 cells. In the present study, the effects of alpha3 integrin activation on the proximal events of IL-1...