Original paper
Rapid structural characterization ofin vivoandin vitrometabolites of tinoridine using UHPLC-QTOF-MS/MS andin silicotoxicological screening of its metabolites
Abstract
Tinoridine is a nonsteroidal anti-inflammatory drug and also has potent radical scavenger and antiperoxidative activity. However, metabolism of tinoridine has not been thoroughly investigated. To identify in vivo metabolites, the drug was administered to Sprague-Dawley rats (n = 5) at a dose of 20 mg kg(-1), and blood, urine and feces were collected at different time points up to 24 h. In vitro metabolism was delved by incubating the drug with...
Paper Details
Title
Rapid structural characterization ofin vivoandin vitrometabolites of tinoridine using UHPLC-QTOF-MS/MS andin silicotoxicological screening of its metabolites
Published Date
Sep 15, 2015
Journal
Volume
50
Issue
11
Pages
1222 - 1233
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Notes
History