Pulmonary Effects of IV Injection of Crushed Oral Tablets: “Excipient Lung Disease”

When crushed oral tablets are injected i.v., their filler material (excipient) can induce a potentially fatal foreign-body reaction in pulmonary arterioles, presenting as dyspnea and pulmonary hypertension with centrilobular nodules on CT. We will describe the imaging and pathologic features of "excipient lung disease."The radiologist has a critical role in recognizing and reporting excipient lung disease because the referring clinician may be...