Mice Lacking the Major Adult GABA_A Receptor Subtype Have Normal Number of Synapses, But Retain Juvenile IPSC Kinetics Until Adulthood

There is a large variation in structurally and functionally different GABA A receptor subtypes. The expression pattern of GABA A receptor subunits is highly regulated, both temporarily and spatially. Especially during development, profound changes in subunit expression have been described. In most brain areas, the GABA A receptor α1 subunit replaces the α2 and/or α3 subunit as major α subunit. This is accompanied by a marked decrease in the open...