Ethyl pyruvate administration inhibits hepatic tumor growth
Abstract
The first demonstration of ethyl pyruvate inhibition of liver tumor growth associated with induction of tumor apoptosis, diminished HMGB1 release, and decreased inflammation is reported. EP is a potent inhibitor of HMGB1 release that has significant anti–inflammatory activities and exerts a protective effect in animal models of inflammation. As inflammation is linked to cancer growth, we hypothesized that EP would have anti–tumor activity and...
Paper Details
Title
Ethyl pyruvate administration inhibits hepatic tumor growth
Published Date
Jul 7, 2009
Journal
Volume
86
Issue
3
Pages
599 - 607
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