Original paper
Doxorubicin blocks proliferation of cancer cells through proteolytic activation of CREB3L1
Abstract
Doxorubicin is used extensively for chemotherapy of diverse types of cancer, yet the mechanism through which it inhibits proliferation of cancer cells remains unclear. Here we report that doxorubicin stimulates de novo synthesis of ceramide, which in turn activates CREB3L1, a transcription factor synthesized as a membrane-bound precursor. Doxorubicin stimulates proteolytic cleavage of CREB3L1 by Site-1 Protease and Site-2 Protease, allowing the...
Paper Details
Title
Doxorubicin blocks proliferation of cancer cells through proteolytic activation of CREB3L1
Published Date
Dec 18, 2012
Journal
Volume
1
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Notes
History