Original paper
Effects of perhexiline-induced fuel switch on the cardiac proteome and metabolome
Abstract
Perhexiline is a potent anti-anginal drug used for treatment of refractory angina and other forms of heart disease. It provides an oxygen sparing effect in the myocardium by creating a switch from fatty acid to glucose metabolism through partial inhibition of carnitine palmitoyltransferase 1 and 2. However, the precise molecular mechanisms underlying the cardioprotective effects elicited by perhexiline are not fully understood. The present study...
Paper Details
Title
Effects of perhexiline-induced fuel switch on the cardiac proteome and metabolome
Published Date
Feb 1, 2013
Volume
55
Pages
27 - 30
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History